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Cerebral Circulation

Dear Colleagues,

The brain is the most energy-intensive organ in the human body. Because of the limited capacity of neurons for anaerobic metabolism, the adult human brain receives up to 20% of cardiac output though it only weights about 2% of body weight. Thus, it is critically important to maintain a constant cerebral blood flow (CBF) for brain function and viability. Cerebral autoregulation is the homeostatic mechanism to keep CBF relatively constant despite changes in cerebral perfusion pressure. Although the physiological origin of cerebral autoregulation has been linked to myogenic, metabolic, and neurogenic processes, the mechanisms are not completely understood. At the microcirculatory level, the entire cerebrovascular system is subjected to a tight regulation named neurovascular coupling, which ensures regional concordance between neuronal activity and the blood supply. Many candidates have been associated with neurovascular coupling, such as vasoactive neurotransmitters, vasoactive ions, vasoactive mediators, and metabolic factors, however, the mechanisms are still poorly understood. Abnormal cerebral autoregulation and neurovascular coupling have been identified in a wide range of diseases, such as Alzhermer’s disease, schizophrenia, Parkinson’s disease, diabetes, hypertension, and stroke, which makes it important to understand their mechanisms. In this special issue we will focus on the possible molecular mechanisms underlying impaired cerebral autoregulation and neurovascular coupling during acute and chronic medical conditions.

Dr. Hong Sun

Professor William G. Mayhan

Guest Editors


Cerebral autoregulation

neurovascular coupling

Alzheimer’s disease


Parkinson’s disease




Submission Deadline: 30 November 2019

Online Submission

Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Med One and then gathered together on the special issue webpage. We welcome Research articles, Review papers and Short Communications. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Guest Editor

  • William G. Mayhan

    Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota

  • Hong Sun

    Department of Cellular Biology and Anatomy, LSU Health Sciences Center – Shreveport

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