Huntington's disease is a familial, progressive neurodegenerative disorder. It is an autosomal dominantly inherited condition caused by the trinucleotide repeat expansion (CAG) in the huntingtin (HTT) gene, located on 4p16 chromosome. The CAG repeat numbers, encoding glutamine, are more than 37 in Huntington's. It has a distinct phenotype comprises physical, cognitive, psychiatric and behavioural difficulties. The clinical features are characterised by both hyperkinetic and hypokinetic symptoms such as chorea, dystonia, rigidity, incoordination and bradykinesia and dementia. This virtual special issue is inviting primary research, review, meta-analysis articles focussing on molecular genetics, new developments in the underlying mechanisms in pathophysiology and potential new treatments of Huntington's disease.
Dr. Suresh KomatiGuest Editor
Submission Deadline: 30 August 2019
Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Med One and then gathered together on the special issue webpage. We welcome Research articles, Review papers, Meta-Analysis articles, and Perspectives. There are no word limits for each article type. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for approval.
Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.
All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.
Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.
Walkergate Park Hospital, NTW NHS Foundation Trust, UK