Self-association, misfolding or misassembly of selected proteins has been linked to a broad range of degenerative human diseases, collectively termed as “amyloid diseases”. These degenerative disorders extend from Alzheimer’s and Parkinson disease, type II diabetes mellitus (TIIDM), obesity to associated prion diseases, polyglutamine diseases, familial transthyretin amyloidosis, immunoglobin amyloid light chain amyloidosis, AA amyloidosis and many more. Amyloid, which is the pathological hallmark of these diseases, consists of fibrils or thread like structures containing misfolded formation of highly rich β-pleated protein structure. Several convincing biochemical, pathologic and genetic studies demonstrated that the misfolded protein aggregation is the primary cause of postmiotic tissue/cell dysfunction or loss. It was also established that the rate of self-association of proteins depends on the rate of accumulation of sheet structure. This also supports that this type of secondary structure in a protein promotes self-aggregation of proteins. However the exact mechanism of fibrilization process and protein aggregation to tissue degeneration leading to pathogenesis is not fully understood. This special issue will cover the comprehensive insight of factors, forces and energies that govern the fibrillization, self-association and irreversible aggregate formation, as well as the structure-activity correlation to cellular toxicity, which are needed to develop potential therapies for intervention of “amyloid disorders”.
Dr. Sarmiatha Basak
Dr. Ajoy BasakGuest Editors
Submission Deadline: 31 March 2020
Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Med One and then gathered together on the special issue webpage. We welcome Research articles, Review papers, Meta-Analysis articles, and Perspectives. There are no word limits for each article type. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for approval.
Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.
All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.
Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.
Kidney Research Center, Ottawa Hospital Research Institute, Uottawa, Canada
Ottawa Hospital Research Institute, U Ottawa, Canada