Transglutaminases are a family of enzymes which catalyze the crosslinking of proteins, linking the epsilon group of a lysine residue in one protein to the carboxyl group of a glutamine residue in a second protein. Identified in plants, microbes and animals, transglutaminases are involved in a diverse range of biological functions. They find industrial usage in the food industry, with multiple applications as gelling and binding agents. In vivo, transglutaminase activity promotes formation of barriers, stabilises structures such as blood clots, and supports wound healing. Transglutaminases have also been shown to modify intracellular and extracellular proteins, and promote protein aggregate formation in a range of pathological states including neurodegenerative diseases, celiac disease and cancer. In recent years, transglutaminase inhibitors have progressed into clinical trials, with encouraging results - particularly in patients with celiac disease and kidney fibrosis - likely to support efforts to expand the potential of this approach into other conditions linked to aberrant transglutaminase activity. This special issue will focus on the biology of the transglutaminase enzyme family, and the potential in targeting these enzymes for the treatment of a diverse range of transglutaminase-linked conditions.
Dr. Nicholas PeakeGuest Editor
Submission Deadline: 30 April 2020
Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Med One and then gathered together on the special issue webpage. We welcome Research articles, Review papers, Meta-Analysis articles, and Perspectives. There are no word limits for each article type. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for approval.
Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.
All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.
Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.
Sheffield Hallam University, UK